人們一提到更年期，腦海中就會立刻出現相關詞匯，如中老年婦女、衰老、情緒異常等。
因為大多數人都認為更年期是女性的專屬。
其實男人也有更年期，隻是常常被大家忽略。
有些人甚至在不知情的情況下經歷了更年期。
男性更年期是指男性激素分泌在青年時期達到頂峰後逐漸下降而引起的一系列生理變化和臨床症狀。
40歲至70歲的男性中，約有40%會出現一些症狀。
LOH的症狀非常復雜，包括身體和身體症狀失眠、多夢、食欲不振、皮膚和肌肉松弛、骨骼和關節疼痛、經常感到腰酸腿軟、腹部肥胖等。
精神不集中、記憶力減退、健忘、效率低下、急躁、易怒和焦慮。
Male menopause refers to a series of physiological changes and clinical symptoms caused by the gradual decline of male hormone secretion after reaching its peak in youth. About 40% of men between the ages of 40 and 70 will experience some symptoms. The symptoms of LOH are very complex，including physical and physical symptoms of insomnia，dreaminess，loss of appetite，skin and muscle relaxation，bone and joint pain，often feel sore waist and soft legs，abdominal obesity，etc. Mental inattention，memory loss，forgetfulness，low efficiency，impatience，irritability and anxiety.
無論男女，更年期是每個人都有的生理過程，是由盛向衰的過渡階段。
但與女性不同的是，男性更年期是一個更長、漸進的過程。
它通常從40歲或45歲開始，並在接下來的20年左右波動。
其實很多人對男性更年期還持懷疑態度，認為我沒有什麼明顯的症狀啊?這是因為男性更年期有明顯的個體差異，相當一部分男性更年期比較輕微，甚至不知道更年期已經不知不覺地進入老年。
In fact，many people are still skeptical about male menopause，thinking that I do not have any obvious symptoms ah? This is because there are obvious individual differences in male menopause，a considerable number of men are relatively mild，and even unaware of menopause has entered old age unconsciously.
男性更年期與NMN有何關系?根據日本eunmn營養學家的說法有以下兩個方面。
首先，男性的睪酮水平從中年開始以每年0.5到2的速度逐漸下降，睪酮是一種類固醇激素，對男性非常重要。
主要用於維持男性身體機能、肌肉力量和質量，維持骨密度。
男性更年期與睪酮水平密切相關。
睪酮產生實驗表明，通過EUNMN通過介導SIRT1反應來幫助產生睪酮。
SIRT1是一種依賴NAD+的去乙酰化酶。
NAD+介導SIRT1調節類固醇的環境平衡，NAD+含量降低會導致SIRT1功能減弱，睪酮含量降低。
增加NAD+可以促進神經遞質多巴胺的合成，增強神經系統的活力，改善情緒和精神狀態。
What is the relationship between male menopause and NMN? According to eunmn nutritionist in Japan，there are two aspects as follows.
First，men’s testosterone levels gradually decline from middle age at a rate of 0.5 to 2 per year，testosterone is a steroid hormone that is very important for men. It is mainly used to maintain male body function，muscle strength and quality，and maintain bone density. Male menopause is closely related to testosterone levels. Testosterone production experiments have shown that NMN helps produce testosterone by mediating the SIRT1 response. SIRT1 is a NAD+ dependent deacetylase. NAD+ mediates SIRT1 to regulate the environmental balance of steroids，and the decrease of NAD+ content will lead to the weakening of SIRT1 function and the decrease of testosterone content. Increased NAD+ can improve the synthesis of the neurotransmitter dopamine，enhance the vitality of the nervous system，and enhance mood and mental state.
美國內華達大學醫學院生理學和細胞生物學學院發表的一篇論文表明，NAD+作為一種神經遞質，可以舒緩平滑肌細胞。
NAD+受大腦調控和釋放，作用於血小板源性生長因子受體A釋放鈣離子，激活鉀離子通道釋放鉀離子，形成抑制性連接電位。
導致平滑肌細胞擴張。
NAD+在這個過程中消耗很快，如果不能及時補充，可能會造成平滑肌細胞難以擴張，從而影響夫妻生活。
The School of Physiology and Cell Biology at the University of Nevada School of Medicine published a paper showing that NAD+ acts as a neurotransmitter to soothe smooth muscle cells. NAD+ is regulated and released by the brain，acting on platelet-derived growth factor receptor A to release calcium ions，activating potassium ion channels to release potassium ions，and forming inhibitory linking potentials. Which directs smooth muscle cells to dilate. NAD+ is consumed quickly in this process，and if it cannot be supplemented in time，it may cause smooth muscle cells to be difficult to dilate，thus affecting the life of husband and wife.
其次，認知功能是指人體高級中樞神經系統識別物質和獲取知識，並將其轉化為內在活力和心理活動的能力和過程。
它主要是指人腦對環境的認識和對事物的理解所進行的持續不斷的思維活動過程，以及執行能力。
包括學習、記憶、語言、計算、心理、情感、行為、表達、空間定向、分析判斷能力和反應能力，以及自我和環境決定能力。
在日本的臨床試驗中得到證實。
增加EUNMN的攝入量已被證明可以增強健康的大腦功能，並可能預防與年齡相關的認知功能喪失。
通過增強大腦線粒體活力，改變供氧能力，減少氧化物積累，保護大腦神經，同時改善腦血流和前額葉皮層氧代謝的影響，提高認知和注意力，以及抗壓力、焦慮和疲勞。
Confirmed in a clinical trial in Japan. Increasing NMN intake has been shown to enhance healthy brain function and may prevent age-related loss of cognitive function. By enhancing the brain’s mitochondrial vitality，changing oxygen supply capacity，reducing oxide accumulation，and protecting the brain’s nerves，while improving the impact of cerebral blood flow and oxygen metabolism in the prefrontal cortex，improving cognition and attention，as well as resistance to stress，anxiety and fatigue.
加強身心素質，合理安排生活和工作對男性更年期非常重要。
生活就是運動，這對中老年男性尤其重要！體育鍛煉重要在堅持，強調適度切不可三天打魚，兩天曬網，閑做，忙不做。
世界衛生組織建議成年人每周鍛煉5次，每次30分鐘。
而且運動強度至少要適中，如果你是運動愛好者，可以繼續按照適合自己的運動量進行。
加強自我管理。
要控制工作量、控制情緒、控制飲食。
有研究表明經常飲酒、吸煙、大量飲濃茶或濃咖啡不合理的膳食習慣、夜班工作者強腦力勞動者、長期處於緊張狀態的人易出現亞健康狀態和更年期綜合征症狀。
所以要控制工作量、控制情緒、控制飲食才能更好地度過更年期。
Strengthening physical and psychological quality reasonable arrangement of life and work is very important for male menopause.
Life is sport，which is especially important for middle-aged and elderly men！ Physical exercise is important in persistence，emphasis on moderation must not be three days fishing，two days drying nets，free to do，busy do not do. The World Health Organization recommends 30 minutes of exercise five times a week for adults. And the exercise should be at least moderate intensity，if you are a sports enthusiast，you can continue to follow the amount of exercise that is suitable for you.